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Fructose Sets Table For Weight Gain Without Warning

Common sweetener found in many foods leads to leptin resistance and exacerbates obesity when paired with high-calorie, high-fat diet

Eating too much fructose can induce leptin resistance, a condition that can easily lead to becoming overweight when combined with a high-fat, high-calorie diet, according to a new study with rats.

Although previous studies have shown that being leptin resistant can lead to rapid weight gain on a high-fat, high-calorie diet, this is the first study to show that leptin resistance can develop as a result of high fructose consumption. The study also showed for the first time that leptin resistance can develop silently, that is, with little indication that it is happening.

The study, “Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding,” was carried out by Alexandra Shapiro, Wei Mu, Carlos Roncal, Kit-Yan Cheng, Richard J. Johnson and Philip J. Scarpace, all at the University of Florida College of Medicine in Gainesville. The study appears in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, published by The American Physiological Society.

“This study may explain how the global increase in fructose consumption is related to the current obesity epidemic,” Shapiro said.

Brain signals less satisfaction for obese people, research shows

Obese individuals may overeat because they experience less satisfaction from eating food due to a reduced response in their brains' reward circuitry, according to a new study by Eric Stice, psychology researcher at the University of Texas at Austin.

Internet Press Office 16 Oct 08

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